… gene expression and protein synthesis in the infected host cell, which … drug that functions
by inhibiting the HIV aspartyl protease—was shown to prevent lytic egress and the cell-to-cell …

… of host-cell protein synthesis, and enhancement of virus DNA … adenovirus replication in HepG2
cells, and 2-Aminopurine … and serum components and to prevent sequestration by MPS in …

… to proteostasis defects by tuning protein synthesis. The ISR is … developed drug-like
small-molecule ISR inhibitor that is … (156) and can be prevented by ISRIB in a human cellular three-…

… For example, by binding tightly to PKR, adenovirus VA RNA … role in the initiation of protein
synthesis. The overall amounts … mRNA in the intact cell is blocked by 2-aminopurine or by the …

… Since no drugs are currently approved for the treatment of adenovirus… FCV could potentially
be a first-in-class adenovirus inhibitor. … FCV prevented the ability of the UL97 kinase to inhibit …

… whether adding synthesized circPOLR2A_Lig could prevent PKR … For example, 2-aminopurine
(2-AP) is an inhibitor of PKR … mM) on downstream cytokine protein production were barely …

… A significant example is represented by 2Aminopurine (4) in … , is a PknB inhibitor capable of
preventing mycobacterial cell … inhibitor of PknB, suggesting a strategy for drug design based …

… of adenovirus is that we are asking adenovirus to behave in a manner in which it does not
behave in the wild. The virus probably infects a small focus of cells… genes is also blocked at the …

… a cellular defence system that reduces protein synthesis to … only a partial inhibitor of PKR
and so, although it prevents a … cell lines the drug ISRIB (integrated stress response inhibitor […

… on drug-treated and infected GFP-expressing cells that were fixed … in cells treated with 0.25
µM drug relative to vehicle-treated … decreased protein synthesis by preventing methionine …